Dysfunctional uterine bleeding (DUB) is a condition that causes vaginal bleeding to occur outside of the regular menstrual cycle. Certain hormonal conditions and medications may be responsible for DUB.
DUB, also called abnormal uterine bleeding (AUB), is a condition that affects nearly every woman at some point in her life.
The major cause of dysfunctional uterine bleeding is an imbalance in the sex hormones. Girls experiencing puberty and women entering menopause can have imbalanced hormone levels for months or even years. This causes irregular bleeding, heavy bleeding, and/or spotting. Spotting is lighter than a normal menstrual bleeding. The colour of blood for spotting ranges from brown, pink, or light red.
The hormonal imbalances that cause DUB can also result from certain medical conditions or be side effects of medications.
Causes of Dysfunction Uterine Bleeding
Medical conditions that often cause dysfunctional uterine bleeding are:
- Polycystic ovary syndrome (PCOS): This condition causes a woman to produce an increased amount of sex hormones. This endocrine disorder may lead to an imbalance in estrogen and progesterone, making the menstrual cycle irregular.
- Endometriosis: This occurs when the uterine lining grows outside of the uterus, such as on the ovaries. Endometriosis regularly causes heavy bleeding during regular periods.
- Uterine polyps: These are small growths that occur within the uterus. Although their cause is unknown, polyp growth is heavily influenced by the hormone estrogen. Small blood vessels in the polyps can cause DUB, including spotting between periods.
- Uterine fibroid: These are small growths that occur within the uterus, uterine lining, or uterine muscle. The causes of uterine fibroids are unknown. However, experts suspect estrogen play a role in their growth.
- Sexually transmitted diseases (STDs): STDs like gonorrhea and chlamydia may lead to DUB. Bleeding caused by STDs usually occurs after sex, when the lesions are provoked.
Certain medications can also cause dysfunctional uterine bleeding, including:
- hormonal agents
- warfarin (Coumadin)
- birth control pills
Symptoms of Dysfunctional Uterine Bleeding
The most common symptom of DUB is bleeding outside of your normal periods. It can also occur within your menstrual cycle. Bleeding patterns to watch out for include:
- bleeding that contains many clots or large clots
- heavy menstrual bleeding
- bleeding that lasts more than seven days
- bleeding that occurs less than 21 days from the last cycle
- bleeding between periods
Other common symptoms that can occur with DUB are:
- breast tenderness
- pelvic pain or pressure
If you experience any of the following severe DUB symptoms, contact your doctor immediately:
- severe weakness
- pale skin
- passing large clots in menstrual bleeding
- increased heart rate
- severe pain
- pad getting soaked in every hour
- low blood pressure
Your doctor will ask questions about your medical history and the history of your cycle. These answers will help them rule out other factors. Inform your doctor if you are taking any medication, including birth control pills, as such drugs cause abnormal bleeding.
Blood tests are used to measure your hormone levels and your complete blood count. Your hormone levels can often give quick understanding into the cause of your bleeding. If you’ve had heavy or extended bleeding, a complete blood count reveals whether your red blood cell count is too low. A low red blood cell count can point to anemia.
Your doctor may recommend an ultrasound to examine your reproductive organs. This examination will reveal whether you have any abnormal growths such as polyps or fibroids. It can also help to rule out internal bleeding.
If an abnormal growth is causing the bleeding, or your uterine lining is abnormally thick, your doctor will take a sample of the uterine tissue for testing. If there are any abnormal cell changes in the lining, a biopsy will reveal it. Abnormal cells can indicate hormone imbalances or cancer, among other things.
Treatment for DUB
There are many treatment options available for DUB. Sometimes, in cases of puberty especially, no action is taken, as the hormones usually correct themselves. The right treatment for you will depend on the cause of the bleeding.
The most common and simple treatment option for dysfunctional uterine bleeding is combination oral contraceptives that contain synthetic estrogen and progesterone. These both work to regulate the menstrual cycle. Contraceptive methods including some IUDs and the implant can also be used as hormonal treatment. If you aren’t trying to conceive, your doctor may recommend using one of these as a treatment option.
If the bleeding is suddenly very heavy and lower-dose medications aren’t an option, intravenous estrogen can be administered until the bleeding subsides. This is normally followed by a course of oral progestin to balance the hormones.
If you’re trying to conceive and you don’t have heavy bleeding, your doctor may prescribe the ovulation-stimulating drug clomiphene, also called clomid. Stimulating ovulation can stop prolonged menstrual bleeding by resetting your menstrual cycle.
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Heavy and prolonged bleeding accompanied by a thickened uterine lining can be treated with a procedure called dilation and curettage (D and C). This is an outpatient surgical procedure used to remove part of the uterine lining by scraping it away.
If your uterine cells are found to be abnormal, your doctor may order an additional biopsy after treatment. Hysterectomy may be recommended, depending on the results of the biopsy, if the cells are cancerous. A hysterectomy is a complete removal of the uterus and is usually a last resort.
Generally, DUB is a temporary condition. Once the sex hormones are controlled, abnormal bleeding usually subsides. One of the main complications of heavy bleeding is anemia. If you develop anemia due to significant blood loss, your doctor may treat it with minerals and vitamin supplements. In rare cases, blood transfusion may be required where the bleeding has caused significant blood loss.