Acne is mostly predominant during teenage years, and even still persist into adulthood for most people. Research has shown that persistent acne causes discomfort and psychological distress. It causes people to become self-aware of their appearance.
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Some of the most common treatments for acne include antibiotics and retinoids which help maintain skin appearance. These traditional treatments are not always effective, and they can cause further unwanted effects — the least severe of which include dry skin and irritation.
“Current treatment options are often not effective or tolerable for many of the 85 percent of adolescents and more than 40 million adults in the United States who suffer from this multi-factorial cutaneous inflammatory condition,” explains researcher Chun-Ming Huang, at the University of California, San Diego. Huang added that effective treatments are truly needed and has been working with his team.
A novel vaccine to get rid of target acne
Huang and his team of researchers explained their process in developing an effective and safe vaccine to eliminate acne.
In a new study now feature in the Journal of Investigative Dermatology, the scientists were able to establish that they could combat the toxin secreted by the bacteria involved in acneiform outbreaks with an antibody. This method also helped reduce acne-related inflammation.
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The researchers also noted that a bacterium called Propionibacterium acnes, produces a toxin called the Christie-Atkins-Munch-Peterson (CAMP) factor. The CAMP factor is responsible for inflammation in acne lesions.
The researchers tested the efficacy of a set of monoclonal antibodies by working with a mouse model and skin cells collected from humans against the CAMP factor. The efforts of the researchers have been promising, and the antibodies proved effective against the inflammation-inducing properties of the toxin.
Huang explains that once authorized by a large-scale clinical trial, the potential impact of the results is huge for the hundreds of millions of individuals suffering from acne vulgaris.